Assay Detail
Binding
CHEMBL4047159
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Inhibition of p53 binding to MDMX (unknown origin) after 30 mins by SPR analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
d-Amino acid mutation of PMI as potent dual peptide inhibitors of p53-MDM2/MDMX interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.33 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3347578 | — | — | 1 | 8.07 |
| CHEMBL4075572 | — | — | 1 | 7.73 |
| CHEMBL4090785 | — | — | 1 | 7.67 |
| CHEMBL4099164 | — | — | 1 | 7.21 |
| CHEMBL4076935 | — | — | 1 | 7.07 |
| CHEMBL4059725 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3347578 | — | Kd | = | 8.5 | nM | 8.07 |
| CHEMBL4075572 | — | Kd | = | 18.5 | nM | 7.73 |
| CHEMBL4090785 | — | Kd | = | 21.4 | nM | 7.67 |
| CHEMBL4099164 | — | Kd | = | 61.3 | nM | 7.21 |
| CHEMBL4076935 | — | Kd | = | 84.4 | nM | 7.07 |
| CHEMBL4059725 | — | Kd | = | 614.0 | nM | 6.21 |