Assay Detail
Functional
CHEMBL4047194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of mitoxantrone induced antiproliferative activity against human H460 cells assessed as mitoxantrone IC50 at 1 uM preincubated for 2 hrs followed by mitoxantrone addition measured after 72 hrs by MTT assay (Rvb = 0.215 +/- 0.011 microM)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.57 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083323 | — | — | 1 | 6.75 |
| CHEMBL410316 | FUMITREMORGIN | — | 1 | 6.73 |
| CHEMBL4061497 | — | — | 1 | 6.71 |
| CHEMBL4096070 | — | — | 1 | 6.69 |
| CHEMBL4078022 | — | — | 1 | 6.68 |
| CHEMBL4074879 | — | — | 1 | 6.68 |
| CHEMBL4081645 | — | — | 1 | 6.68 |
| CHEMBL4096318 | — | — | 1 | 6.68 |
| CHEMBL4065537 | — | — | 1 | 6.67 |
| CHEMBL4077458 | — | — | 1 | 6.67 |
| CHEMBL4064511 | — | — | 1 | 6.66 |
| CHEMBL4084461 | — | — | 1 | 6.66 |
| CHEMBL4102415 | — | — | 1 | 6.66 |
| CHEMBL4095392 | — | — | 1 | 6.66 |
| CHEMBL4092211 | — | — | 1 | 6.66 |
| CHEMBL4080817 | — | — | 1 | 6.64 |
| CHEMBL3426387 | — | — | 1 | 6.62 |
| CHEMBL4091036 | — | — | 1 | 6.62 |
| CHEMBL3426388 | — | — | 1 | 6.61 |
| CHEMBL4072882 | — | — | 1 | 6.61 |
| CHEMBL4092046 | — | — | 1 | 6.59 |
| CHEMBL4076705 | — | — | 1 | 6.59 |
| CHEMBL4099768 | — | — | 1 | 6.59 |
| CHEMBL4102382 | — | — | 1 | 6.55 |
| CHEMBL4076726 | — | — | 1 | 6.53 |
| CHEMBL3885456 | — | — | 1 | 6.52 |
| CHEMBL4098858 | — | — | 1 | 6.47 |
| CHEMBL4087699 | — | — | 1 | 6.34 |
| CHEMBL4069054 | — | — | 1 | 6.30 |
| CHEMBL4066351 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083323 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL410316 | FUMITREMORGIN | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4061497 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4096070 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4078022 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4074879 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4081645 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4096318 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4065537 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4077458 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL4064511 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4084461 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4102415 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4095392 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4092211 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4080817 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3426387 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4091036 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL3426388 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4072882 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4092046 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4076705 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL4099768 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4102382 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL4076726 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL3885456 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL4098858 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4087699 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4069054 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL4066351 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL4104064 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL4077603 | — | IC50 | = | 725.0 | nM | 6.14 |