Assay Detail
Binding
CHEMBL4047448
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Binding affinity to LSD1 (unknown origin) by SPR analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 6.38 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134377 | — | — | 1 | 8.10 |
| CHEMBL4071991 | — | — | 1 | 7.66 |
| CHEMBL4066130 | — | — | 1 | 7.32 |
| CHEMBL4100487 | — | — | 1 | 7.21 |
| CHEMBL4092760 | — | — | 1 | 7.01 |
| CHEMBL4087724 | — | — | 1 | 6.96 |
| CHEMBL4082476 | — | — | 1 | 6.92 |
| CHEMBL4105603 | — | — | 1 | 6.72 |
| CHEMBL4079847 | — | — | 1 | 6.37 |
| CHEMBL4079770 | — | — | 1 | 6.27 |
| CHEMBL4097870 | — | — | 1 | 6.21 |
| CHEMBL4074738 | — | — | 1 | 6.11 |
| CHEMBL4063365 | — | — | 1 | 6.02 |
| CHEMBL4101423 | — | — | 1 | 5.85 |
| CHEMBL4085006 | — | — | 1 | 5.77 |
| CHEMBL4093703 | — | — | 1 | 5.70 |
| CHEMBL4104027 | — | — | 1 | 4.42 |
| CHEMBL4066293 | — | — | 1 | 4.28 |
| CHEMBL4087649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134377 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL4071991 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4066130 | — | Kd | = | 48.0 | nM | 7.32 |
| CHEMBL4100487 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL4092760 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL4087724 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL4082476 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL4105603 | — | Kd | = | 190.0 | nM | 6.72 |
| CHEMBL4079847 | — | Kd | = | 430.0 | nM | 6.37 |
| CHEMBL4079770 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL4097870 | — | Kd | = | 610.0 | nM | 6.21 |
| CHEMBL4074738 | — | Kd | = | 770.0 | nM | 6.11 |
| CHEMBL4063365 | — | Kd | = | 950.0 | nM | 6.02 |
| CHEMBL4101423 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL4085006 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL4093703 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL4104027 | — | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL4066293 | — | Kd | = | 53000.0 | nM | 4.28 |
| CHEMBL4087649 | — | Kd | > | 100000.0 | nM | - |