Assay Detail
Functional
CHEMBL4047582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.32 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3341972 | — | — | 1 | 8.22 |
| CHEMBL3115775 | — | — | 1 | 7.80 |
| CHEMBL4084871 | — | — | 1 | 7.64 |
| CHEMBL4081391 | — | — | 1 | 6.24 |
| CHEMBL4091674 | — | — | 1 | 6.14 |
| CHEMBL4070005 | — | — | 1 | 5.95 |
| CHEMBL4070795 | — | — | 1 | 5.88 |
| CHEMBL4090987 | — | — | 1 | 5.87 |
| CHEMBL4096962 | — | — | 1 | 5.39 |
| CHEMBL4096265 | — | — | 1 | 5.26 |
| CHEMBL4069768 | — | — | 1 | 5.09 |
| CHEMBL3341971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3341972 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3115775 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4084871 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4081391 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4091674 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4070005 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4070795 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4090987 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4096962 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4096265 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4069768 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL3341971 | — | IC50 | = | 2700.0 | nM | - |