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Assay Detail

CHEMBL4047718

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility.
Huang G, Drakopoulos A, Saedtler M, Zou H, Meinel L, Heilmann J, Decker M.
Bioorg Med Chem Lett (2017) 27 : 4937 -4941
PubMed 28958621 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 4.81 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL338474 HELENALIN 1 6.16
CHEMBL85106 1 5.14
CHEMBL4084479 1 5.08
CHEMBL4066608 1 5.01
CHEMBL4103261 1 4.95
CHEMBL4065556 1 4.81
CHEMBL4103376 1 4.79
CHEMBL4093217 1 4.77
CHEMBL4081364 1 4.69
CHEMBL4085453 1 4.66
CHEMBL85139 RUTAECARPINE 1 4.58
CHEMBL4074179 1 4.27
CHEMBL315422 1 4.22
CHEMBL4100940 1 4.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL338474 HELENALIN EC50 = 700.0 nM 6.16
CHEMBL85106 EC50 = 7200.0 nM 5.14
CHEMBL4084479 EC50 = 8400.0 nM 5.08
CHEMBL4066608 EC50 = 9800.0 nM 5.01
CHEMBL4103261 EC50 = 11300.0 nM 4.95
CHEMBL4065556 EC50 = 15400.0 nM 4.81
CHEMBL4103376 EC50 = 16300.0 nM 4.79
CHEMBL4093217 EC50 = 17100.0 nM 4.77
CHEMBL4081364 EC50 = 20600.0 nM 4.69
CHEMBL4085453 EC50 = 22100.0 nM 4.66
CHEMBL85139 RUTAECARPINE EC50 = 26100.0 nM 4.58
CHEMBL4074179 EC50 = 53900.0 nM 4.27
CHEMBL315422 EC50 = 60800.0 nM 4.22
CHEMBL4100940 EC50 = 64200.0 nM 4.19