Assay Detail
Binding
CHEMBL4047809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild-type HIV-1 protease
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 10.83 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 10.85 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.016 | nM | 10.80 |