Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4047852

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of yeast alpha-glucosidase using 4-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.
Zhang BW, Xing Y, Wen C, Yu XX, Sun WL, Xiu ZL, Dong YS.
Bioorg Med Chem Lett (2017) 27 : 5065 -5070
PubMed 28964635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.65 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169 URSOLIC ACID 2.0 1 4.92
CHEMBL269277 BETULINIC ACID 1.0 1 4.83
CHEMBL391533 COROSOLIC ACID 1 4.76
CHEMBL168 OLEANOLIC_ACID 1 4.45
CHEMBL23236 BETULIN 1 4.28
CHEMBL404313 ASIATIC ACID 1 -
CHEMBL441687 GLYCYRRHIZIN 2.0 1 -
CHEMBL230006 ENOXOLONE 2.0 1 -
CHEMBL1684590 1 -
CHEMBL404271 ACARBOSE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169 URSOLIC ACID IC50 = 12100.0 nM 4.92
CHEMBL269277 BETULINIC ACID IC50 = 14900.0 nM 4.83
CHEMBL391533 COROSOLIC ACID IC50 = 17200.0 nM 4.76
CHEMBL168 OLEANOLIC_ACID IC50 = 35600.0 nM 4.45
CHEMBL23236 BETULIN IC50 = 52500.0 nM 4.28
CHEMBL404313 ASIATIC ACID IC50 = 100200.0 nM -
CHEMBL441687 GLYCYRRHIZIN IC50 > 200000.0 nM -
CHEMBL230006 ENOXOLONE IC50 > 200000.0 nM -
CHEMBL1684590 IC50 > 200000.0 nM -
CHEMBL404271 ACARBOSE IC50 = 2479000.0 nM -