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Assay Detail

CHEMBL4048002

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Functional
Protection against neomycin-induced hair cell death in AB zebra fish larvae assessed as increase in hair cell survival preincubated for 1 hr followed by neomycin challenge for 1 hr by DASPEI staining-based epifluorescence dissecting microscopic method
ChEMBL ↗
99
Total Activities
99
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Danio rerio
Confidence 1 — Organism
Curated By Autocuration

Target

Danio rerio (CHEMBL613963) ↗
Type ORGANISM
Organism Danio rerio

Publication

Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.
Chowdhury S, Owens KN, Herr RJ, Jiang Q, Chen X, Johnson G, Groppi VE, Raible DW, Rubel EW, Simon JA.
J Med Chem (2018) 61 : 84 -97
PubMed 28992413 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 99 5.92 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4095919 — — 1 7.52
CHEMBL4101684 — — 1 7.00
CHEMBL4083107 — — 1 7.00
CHEMBL4062960 — — 1 7.00
CHEMBL4066396 — — 1 6.96
CHEMBL4078668 — — 1 6.96
CHEMBL4069611 — — 1 6.96
CHEMBL4096279 — — 1 6.92
CHEMBL4096686 — — 1 6.85
CHEMBL4101082 — — 1 6.70
CHEMBL4081258 — — 1 6.68
CHEMBL4072626 — — 1 6.68
CHEMBL4090893 — — 1 6.60
CHEMBL4099277 — — 1 6.57
CHEMBL4104558 — — 1 6.57
CHEMBL4064029 — — 1 6.54
CHEMBL4092909 — — 1 6.44
CHEMBL4093341 — — 1 6.44
CHEMBL4085593 — — 1 6.42
CHEMBL4085169 — — 1 6.39
CHEMBL4063637 — — 1 6.35
CHEMBL4093949 — — 1 6.33
CHEMBL4063538 — — 1 6.32
CHEMBL4096357 — — 1 6.25
CHEMBL4104100 — — 1 6.21
CHEMBL4060943 — — 1 6.21
CHEMBL4086193 — — 1 6.15
CHEMBL4085257 — — 1 6.02
CHEMBL4078307 — — 1 5.96
CHEMBL4101606 — — 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4095919 — EC50 = 30.0 nM 7.52
CHEMBL4101684 — EC50 = 100.0 nM 7.00
CHEMBL4062960 — EC50 = 100.0 nM 7.00
CHEMBL4083107 — EC50 = 100.0 nM 7.00
CHEMBL4066396 — EC50 = 110.0 nM 6.96
CHEMBL4078668 — EC50 = 110.0 nM 6.96
CHEMBL4069611 — EC50 = 110.0 nM 6.96
CHEMBL4096279 — EC50 = 120.0 nM 6.92
CHEMBL4096686 — EC50 = 140.0 nM 6.85
CHEMBL4101082 — EC50 = 200.0 nM 6.70
CHEMBL4081258 — EC50 = 210.0 nM 6.68
CHEMBL4072626 — EC50 = 210.0 nM 6.68
CHEMBL4090893 — EC50 = 250.0 nM 6.60
CHEMBL4104558 — EC50 = 270.0 nM 6.57
CHEMBL4099277 — EC50 = 270.0 nM 6.57
CHEMBL4064029 — EC50 = 290.0 nM 6.54
CHEMBL4092909 — EC50 = 360.0 nM 6.44
CHEMBL4093341 — EC50 = 360.0 nM 6.44
CHEMBL4085593 — EC50 = 380.0 nM 6.42
CHEMBL4085169 — EC50 = 410.0 nM 6.39
CHEMBL4063637 — EC50 = 450.0 nM 6.35
CHEMBL4093949 — EC50 = 470.0 nM 6.33
CHEMBL4063538 — EC50 = 480.0 nM 6.32
CHEMBL4096357 — EC50 = 560.0 nM 6.25
CHEMBL4060943 — EC50 = 620.0 nM 6.21
CHEMBL4104100 — EC50 = 620.0 nM 6.21
CHEMBL4086193 — EC50 = 710.0 nM 6.15
CHEMBL4085257 — EC50 = 960.0 nM 6.02
CHEMBL4078307 — EC50 = 1100.0 nM 5.96
CHEMBL4101606 — EC50 = 1210.0 nM 5.92
CHEMBL4072149 — EC50 = 1240.0 nM 5.91
CHEMBL4086646 — EC50 = 1220.0 nM 5.91
CHEMBL4065205 — EC50 = 1360.0 nM 5.87
CHEMBL4073801 — EC50 = 1490.0 nM 5.83
CHEMBL4070781 — EC50 = 1620.0 nM 5.79
CHEMBL4071833 — EC50 = 1780.0 nM 5.75
CHEMBL4078792 — EC50 = 1830.0 nM 5.74
CHEMBL4103067 — EC50 = 1890.0 nM 5.72
CHEMBL4074997 — EC50 = 1960.0 nM 5.71
CHEMBL4078226 — EC50 = 2250.0 nM 5.65
CHEMBL4067906 — EC50 = 2400.0 nM 5.62
CHEMBL4095314 — EC50 = 2830.0 nM 5.55
CHEMBL4082334 — EC50 = 2910.0 nM 5.54
CHEMBL4074914 — EC50 = 3100.0 nM 5.51
CHEMBL4062161 — EC50 = 3120.0 nM 5.51
CHEMBL4090182 — EC50 = 3130.0 nM 5.50
CHEMBL4060661 — EC50 = 3260.0 nM 5.49
CHEMBL4100354 — EC50 = 3390.0 nM 5.47
CHEMBL4068680 — EC50 = 3500.0 nM 5.46
CHEMBL4082641 — EC50 = 3920.0 nM 5.41