Assay Detail
ADMET
CHEMBL4048012
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Cytotoxicity against human HepG2 cells assessed as decrease in cell growth after 72 hrs by celltiter glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.77 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101684 | — | — | 1 | 4.77 |
| CHEMBL4062161 | — | — | 1 | - |
| CHEMBL4072149 | — | — | 1 | - |
| CHEMBL4096279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101684 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4062161 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL4072149 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL4096279 | — | IC50 | > | 300000.0 | nM | - |