Assay Detail
Binding
CHEMBL4048075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.59 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.72 |
| CHEMBL4069776 | — | — | 1 | 6.89 |
| CHEMBL4089264 | — | — | 1 | 6.42 |
| CHEMBL4091683 | — | — | 1 | 6.37 |
| CHEMBL4075667 | — | — | 1 | 6.08 |
| CHEMBL4066908 | — | — | 1 | 6.05 |
| CHEMBL4096963 | — | — | 1 | 6.00 |
| CHEMBL4061100 | — | — | 1 | 5.96 |
| CHEMBL4096975 | — | — | 1 | 5.89 |
| CHEMBL3547058 | — | — | 1 | 5.68 |
| CHEMBL3547159 | — | — | 1 | 5.58 |
| CHEMBL4104552 | — | — | 1 | 5.48 |
| CHEMBL4089274 | — | — | 1 | 5.47 |
| CHEMBL4076402 | — | — | 1 | 5.47 |
| CHEMBL4066677 | — | — | 1 | 5.44 |
| CHEMBL4091015 | — | — | 1 | 5.34 |
| CHEMBL4099414 | — | — | 1 | 5.31 |
| CHEMBL4061108 | — | — | 1 | 5.31 |
| CHEMBL4085625 | — | — | 1 | 5.28 |
| CHEMBL4086653 | — | — | 1 | 5.21 |
| CHEMBL4081393 | — | — | 1 | 5.17 |
| CHEMBL4080466 | — | — | 1 | 5.10 |
| CHEMBL4094393 | — | — | 1 | 5.09 |
| CHEMBL4070797 | — | — | 1 | 5.06 |
| CHEMBL4077879 | — | — | 1 | 5.03 |
| CHEMBL4104698 | — | — | 1 | 5.02 |
| CHEMBL4086843 | — | — | 1 | 4.89 |
| CHEMBL4064598 | — | — | 1 | 4.87 |
| CHEMBL4066289 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4069776 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4089264 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4091683 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4075667 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4066908 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4096963 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4061100 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4096975 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3547058 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3547159 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4104552 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4089274 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4076402 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4066677 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4091015 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4099414 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4061108 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4085625 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4086653 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4081393 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4080466 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4094393 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4070797 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4077879 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4104698 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4086843 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4064598 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4066289 | — | IC50 | = | 15900.0 | nM | 4.80 |