Assay Detail
Binding
CHEMBL4048089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.20 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.06 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.75 |
| CHEMBL4075667 | — | — | 1 | 5.58 |
| CHEMBL3547159 | — | — | 1 | 5.38 |
| CHEMBL4066908 | — | — | 1 | 5.33 |
| CHEMBL4089274 | — | — | 1 | 5.25 |
| CHEMBL4076402 | — | — | 1 | 5.23 |
| CHEMBL4094393 | — | — | 1 | 5.21 |
| CHEMBL4104698 | — | — | 1 | 5.20 |
| CHEMBL4061108 | — | — | 1 | 5.19 |
| CHEMBL4091683 | — | — | 1 | 5.16 |
| CHEMBL4066677 | — | — | 1 | 5.16 |
| CHEMBL4104552 | — | — | 1 | 5.16 |
| CHEMBL4066289 | — | — | 1 | 5.14 |
| CHEMBL4064598 | — | — | 1 | 5.12 |
| CHEMBL4081393 | — | — | 1 | 5.09 |
| CHEMBL4077879 | — | — | 1 | 5.08 |
| CHEMBL4086653 | — | — | 1 | 5.08 |
| CHEMBL3547058 | — | — | 1 | 5.08 |
| CHEMBL4085625 | — | — | 1 | 5.05 |
| CHEMBL4099414 | — | — | 1 | 5.04 |
| CHEMBL4069776 | — | — | 1 | 5.03 |
| CHEMBL4091015 | — | — | 1 | 5.01 |
| CHEMBL4086843 | — | — | 1 | 4.98 |
| CHEMBL4061100 | — | — | 1 | 4.95 |
| CHEMBL4096975 | — | — | 1 | 4.94 |
| CHEMBL4089264 | — | — | 1 | 4.93 |
| CHEMBL4096963 | — | — | 1 | 4.91 |
| CHEMBL4080466 | — | — | 1 | 4.90 |
| CHEMBL4070797 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4075667 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3547159 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4066908 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4089274 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4076402 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4094393 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4104698 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4061108 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4091683 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4066677 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4104552 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4066289 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4064598 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4081393 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4077879 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4086653 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3547058 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4085625 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4099414 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4069776 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4091015 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4086843 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4061100 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4096975 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4089264 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4096963 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4080466 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4070797 | — | IC50 | = | 13100.0 | nM | 4.88 |