Assay Detail
Binding
CHEMBL4048097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine as substrate incubated for 15 mins by Ellman's method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.04 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.72 |
| CHEMBL4093622 | — | — | 1 | 6.02 |
| CHEMBL4088328 | — | — | 1 | 5.66 |
| CHEMBL4099142 | — | — | 1 | 5.54 |
| CHEMBL4072178 | — | — | 1 | 5.41 |
| CHEMBL4098208 | — | — | 1 | 5.26 |
| CHEMBL4069471 | — | — | 1 | 5.20 |
| CHEMBL4090497 | — | — | 1 | 5.07 |
| CHEMBL4084930 | — | — | 1 | 5.06 |
| CHEMBL4092686 | — | — | 1 | 4.82 |
| CHEMBL4063278 | — | — | 1 | 4.78 |
| CHEMBL4065727 | — | — | 1 | 4.78 |
| CHEMBL4067057 | — | — | 1 | 4.74 |
| CHEMBL4067550 | — | — | 1 | 4.66 |
| CHEMBL4087146 | — | — | 1 | 4.59 |
| CHEMBL4071909 | — | — | 1 | 4.58 |
| CHEMBL4080179 | — | — | 1 | 4.56 |
| CHEMBL4101356 | — | — | 1 | 4.54 |
| CHEMBL4066052 | — | — | 1 | 4.38 |
| CHEMBL4082669 | — | — | 1 | 4.29 |
| CHEMBL4077921 | — | — | 1 | 4.24 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4093622 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4088328 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4099142 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4072178 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4098208 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4069471 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4090497 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4084930 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4092686 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4063278 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4065727 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4067057 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4067550 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4087146 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4071909 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4080179 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL4101356 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4066052 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL4082669 | — | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL4077921 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL887 | RASAGILINE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - |