Assay Detail
Binding
CHEMBL4048104
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Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.16 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.07 |
| CHEMBL4066052 | — | — | 1 | 6.21 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.75 |
| CHEMBL4063278 | — | — | 1 | 5.75 |
| CHEMBL4084930 | — | — | 1 | 5.60 |
| CHEMBL4101356 | — | — | 1 | 5.55 |
| CHEMBL4069471 | — | — | 1 | 5.46 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.30 |
| CHEMBL4098208 | — | — | 1 | 5.21 |
| CHEMBL4093622 | — | — | 1 | 5.17 |
| CHEMBL4092686 | — | — | 1 | 4.93 |
| CHEMBL4067057 | — | — | 1 | 4.92 |
| CHEMBL4072178 | — | — | 1 | 4.91 |
| CHEMBL4080179 | — | — | 1 | 4.82 |
| CHEMBL4071909 | — | — | 1 | 4.82 |
| CHEMBL4082669 | — | — | 1 | 4.81 |
| CHEMBL4088328 | — | — | 1 | 4.80 |
| CHEMBL4067550 | — | — | 1 | 4.78 |
| CHEMBL4087146 | — | — | 1 | 4.68 |
| CHEMBL4099142 | — | — | 1 | 4.58 |
| CHEMBL4090497 | — | — | 1 | 4.57 |
| CHEMBL4065727 | — | — | 1 | 4.51 |
| CHEMBL4077921 | — | — | 1 | 4.46 |
| CHEMBL243374 | — | — | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4066052 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4063278 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4084930 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4101356 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4069471 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4098208 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4093622 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4092686 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4067057 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4072178 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4080179 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4071909 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4082669 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL4088328 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4067550 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4087146 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4099142 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL4090497 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL4065727 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL4077921 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL243374 | — | IC50 | - | — | - | |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |