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Assay Detail

CHEMBL4048130

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Functional
Antiproliferative activity against human PC3 cells treated for 24 hrs measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity.
Hu X, Wang Y, Xue J, Han T, Jiao R, Li Z, Liu W, Xu F, Hua H, Li D.
Bioorg Med Chem Lett (2017) 27 : 4989 -4993
PubMed 29037951 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.58 4.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4093276 1 4.91
CHEMBL81925 1 4.86
CHEMBL4071502 1 4.70
CHEMBL4084559 1 4.67
CHEMBL185 FLUOROURACIL 4.0 1 4.62
CHEMBL4064558 1 4.56
CHEMBL4092295 1 4.56
CHEMBL515 CHLORAMBUCIL 4.0 1 4.38
CHEMBL4102464 1 4.34
CHEMBL12293 1 4.20
CHEMBL4087255 1 -
CHEMBL4065021 1 -
CHEMBL4089465 1 -
CHEMBL4068288 1 -
CHEMBL4067261 1 -
CHEMBL4094713 1 -
CHEMBL4104882 1 -
CHEMBL4087018 1 -
CHEMBL4086081 1 -
CHEMBL4078190 1 -
CHEMBL4062886 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4093276 IC50 = 12310.0 nM 4.91
CHEMBL81925 IC50 = 13970.0 nM 4.86
CHEMBL4071502 IC50 = 19860.0 nM 4.70
CHEMBL4084559 IC50 = 21480.0 nM 4.67
CHEMBL185 FLUOROURACIL IC50 = 23940.0 nM 4.62
CHEMBL4064558 IC50 = 27620.0 nM 4.56
CHEMBL4092295 IC50 = 27260.0 nM 4.56
CHEMBL515 CHLORAMBUCIL IC50 = 42050.0 nM 4.38
CHEMBL4102464 IC50 = 45690.0 nM 4.34
CHEMBL12293 IC50 = 63460.0 nM 4.20
CHEMBL4087255 IC50 > 100000.0 nM -
CHEMBL4065021 IC50 > 100000.0 nM -
CHEMBL4089465 IC50 > 100000.0 nM -
CHEMBL4068288 IC50 > 100000.0 nM -
CHEMBL4067261 IC50 > 100000.0 nM -
CHEMBL4094713 IC50 > 100000.0 nM -
CHEMBL4104882 IC50 > 100000.0 nM -
CHEMBL4087018 IC50 > 100000.0 nM -
CHEMBL4086081 IC50 > 100000.0 nM -
CHEMBL4078190 IC50 > 100000.0 nM -
CHEMBL4062886 IC50 > 100000.0 nM -