Assay Detail
Functional
CHEMBL4048131
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Antiproliferative activity against human HepG2 cells treated for 24 hrs measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.80 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81925 | — | — | 1 | 5.03 |
| CHEMBL4062886 | — | — | 1 | 4.86 |
| CHEMBL4065021 | — | — | 1 | 4.77 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.52 |
| CHEMBL4093276 | — | — | 1 | - |
| CHEMBL4092295 | — | — | 1 | - |
| CHEMBL4071502 | — | — | 1 | - |
| CHEMBL4084559 | — | — | 1 | - |
| CHEMBL12293 | — | — | 1 | - |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
| CHEMBL4102464 | — | — | 1 | - |
| CHEMBL4078190 | — | — | 1 | - |
| CHEMBL4086081 | — | — | 1 | - |
| CHEMBL4087018 | — | — | 1 | - |
| CHEMBL4104882 | — | — | 1 | - |
| CHEMBL4094713 | — | — | 1 | - |
| CHEMBL4067261 | — | — | 1 | - |
| CHEMBL4068288 | — | — | 1 | - |
| CHEMBL4089465 | — | — | 1 | - |
| CHEMBL4087255 | — | — | 1 | - |
| CHEMBL4064558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81925 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL4062886 | — | IC50 | = | 13830.0 | nM | 4.86 |
| CHEMBL4065021 | — | IC50 | = | 17040.0 | nM | 4.77 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 30480.0 | nM | 4.52 |
| CHEMBL4093276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4092295 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4071502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084559 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL12293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL4102464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4078190 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4087018 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4104882 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4094713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4067261 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068288 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089465 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4087255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4064558 | — | IC50 | > | 100000.0 | nM | - |