Assay Detail
ADMET
CHEMBL4048262
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Inhibition of human gamma-secretase expressed in HEK293 cells using Notch1-VP16-Gal4 as substrate after 24 hrs by Bright-Glo luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.10 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059711 | — | — | 1 | 7.77 |
| CHEMBL4075787 | — | — | 1 | 7.57 |
| CHEMBL4064631 | — | — | 1 | 6.21 |
| CHEMBL4077007 | — | — | 1 | 5.73 |
| CHEMBL4069936 | — | — | 1 | 5.21 |
| CHEMBL4100749 | — | — | 1 | 5.11 |
| CHEMBL4076827 | — | — | 1 | 5.09 |
| CHEMBL4077336 | — | — | 1 | - |
| CHEMBL4074838 | — | — | 1 | - |
| CHEMBL4105093 | — | — | 1 | - |
| CHEMBL4086098 | — | — | 1 | - |
| CHEMBL392068 | — | — | 1 | - |
| CHEMBL255473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059711 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4075787 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4064631 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4077007 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4069936 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4100749 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4076827 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4077336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4105093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4086098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL392068 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL255473 | — | IC50 | > | 10000.0 | nM | - |