Assay Detail
ADMET
CHEMBL4048826
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Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate after 60 mins by fluorimeter
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.26 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.45 |
| CHEMBL4065219 | — | — | 1 | 7.18 |
| CHEMBL4062190 | — | — | 1 | 7.15 |
| CHEMBL4084164 | — | — | 1 | 6.63 |
| CHEMBL4100534 | — | — | 1 | 6.51 |
| CHEMBL4072045 | — | — | 1 | 6.50 |
| CHEMBL4101480 | — | — | 1 | 6.43 |
| CHEMBL4065283 | — | — | 1 | 6.33 |
| CHEMBL4075722 | — | — | 1 | 6.32 |
| CHEMBL4085143 | — | — | 1 | 6.12 |
| CHEMBL4087616 | — | — | 1 | 6.11 |
| CHEMBL4083713 | — | — | 1 | 6.03 |
| CHEMBL4073813 | — | — | 1 | 6.00 |
| CHEMBL4074800 | — | — | 1 | 5.87 |
| CHEMBL4066262 | — | — | 1 | 5.50 |
| CHEMBL4092880 | — | — | 1 | 5.28 |
| CHEMBL4081647 | — | — | 1 | 5.21 |
| CHEMBL4062461 | — | — | 1 | 5.14 |
| CHEMBL4103079 | — | — | 1 | - |
| CHEMBL3110004 | — | — | 1 | - |
| CHEMBL4092802 | — | — | 1 | - |
| CHEMBL4082520 | — | — | 1 | - |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | - |
| CHEMBL4100615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | Ki | = | 3.55 | nM | 8.45 |
| CHEMBL4065219 | — | Ki | = | 66.51 | nM | 7.18 |
| CHEMBL4062190 | — | Ki | = | 70.8 | nM | 7.15 |
| CHEMBL4084164 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL4100534 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL4072045 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL4101480 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4065283 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL4075722 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL4085143 | — | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL4087616 | — | Ki | = | 774.0 | nM | 6.11 |
| CHEMBL4083713 | — | Ki | = | 943.0 | nM | 6.03 |
| CHEMBL4073813 | — | Ki | = | 995.0 | nM | 6.00 |
| CHEMBL4074800 | — | Ki | = | 1356.0 | nM | 5.87 |
| CHEMBL4066262 | — | Ki | = | 3195.0 | nM | 5.50 |
| CHEMBL4092880 | — | Ki | = | 5205.0 | nM | 5.28 |
| CHEMBL4081647 | — | Ki | = | 6097.0 | nM | 5.21 |
| CHEMBL4062461 | — | Ki | = | 7244.0 | nM | 5.14 |
| CHEMBL4103079 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3110004 | — | Ki | - | — | - | |
| CHEMBL4092802 | — | Ki | - | — | - | |
| CHEMBL4082520 | — | Ki | - | — | - | |
| CHEMBL2018302 | TUBASTATIN A | Ki | > | 1130.0 | nM | - |
| CHEMBL4100615 | — | Ki | - | — | - |