Assay Detail
Binding
CHEMBL4048827
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Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as substrate after 90 mins by fluorimeter
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.92 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082520 | — | — | 1 | 10.10 |
| CHEMBL4100534 | — | — | 1 | 9.82 |
| CHEMBL4101480 | — | — | 1 | 9.80 |
| CHEMBL4074800 | — | — | 1 | 9.64 |
| CHEMBL4062190 | — | — | 1 | 9.49 |
| CHEMBL4092802 | — | — | 1 | 9.38 |
| CHEMBL4065283 | — | — | 1 | 9.35 |
| CHEMBL4072045 | — | — | 1 | 9.32 |
| CHEMBL4075722 | — | — | 1 | 9.29 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.24 |
| CHEMBL4087616 | — | — | 1 | 9.15 |
| CHEMBL4092880 | — | — | 1 | 9.15 |
| CHEMBL4083713 | — | — | 1 | 9.06 |
| CHEMBL4100615 | — | — | 1 | 8.75 |
| CHEMBL4073813 | — | — | 1 | 8.73 |
| CHEMBL4066262 | — | — | 1 | 8.70 |
| CHEMBL4065219 | — | — | 1 | 8.38 |
| CHEMBL4081647 | — | — | 1 | 8.19 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.12 |
| CHEMBL4084164 | — | — | 1 | 7.85 |
| CHEMBL4062461 | — | — | 1 | 7.52 |
| CHEMBL4085143 | — | — | 1 | 7.14 |
| CHEMBL4103079 | — | — | 1 | - |
| CHEMBL3110004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082520 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL4100534 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL4101480 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4074800 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL4062190 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL4092802 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL4065283 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL4072045 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL4075722 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL4087616 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4092880 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4083713 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL4100615 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL4073813 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL4066262 | — | Ki | = | 2.01 | nM | 8.70 |
| CHEMBL4065219 | — | Ki | = | 4.15 | nM | 8.38 |
| CHEMBL4081647 | — | Ki | = | 6.51 | nM | 8.19 |
| CHEMBL2018302 | TUBASTATIN A | Ki | = | 7.56 | nM | 8.12 |
| CHEMBL4084164 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL4062461 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL4085143 | — | Ki | = | 72.24 | nM | 7.14 |
| CHEMBL4103079 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3110004 | — | Ki | - | — | - |