Assay Detail
ADMET
CHEMBL4048828
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Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC as substrate after 60 mins by fluorimeter
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.43 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085143 | — | — | 1 | 7.88 |
| CHEMBL4065283 | — | — | 1 | 7.39 |
| CHEMBL4062190 | — | — | 1 | 7.03 |
| CHEMBL4100534 | — | — | 1 | 6.91 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.84 |
| CHEMBL4087616 | — | — | 1 | 6.76 |
| CHEMBL4065219 | — | — | 1 | 6.69 |
| CHEMBL4066262 | — | — | 1 | 6.53 |
| CHEMBL4101480 | — | — | 1 | 6.52 |
| CHEMBL4074800 | — | — | 1 | 6.37 |
| CHEMBL4075722 | — | — | 1 | 6.28 |
| CHEMBL4083713 | — | — | 1 | 6.15 |
| CHEMBL4072045 | — | — | 1 | 6.14 |
| CHEMBL4084164 | — | — | 1 | 6.14 |
| CHEMBL4073813 | — | — | 1 | 6.12 |
| CHEMBL4092880 | — | — | 1 | 6.00 |
| CHEMBL4081647 | — | — | 1 | 5.81 |
| CHEMBL4062461 | — | — | 1 | 5.78 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.77 |
| CHEMBL3110004 | — | — | 1 | 5.57 |
| CHEMBL4103079 | — | — | 1 | - |
| CHEMBL4100615 | — | — | 1 | - |
| CHEMBL4082520 | — | — | 1 | - |
| CHEMBL4092802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085143 | — | Ki | = | 13.09 | nM | 7.88 |
| CHEMBL4065283 | — | Ki | = | 40.4 | nM | 7.39 |
| CHEMBL4062190 | — | Ki | = | 93.3 | nM | 7.03 |
| CHEMBL4100534 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL4087616 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL4065219 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL4066262 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL4101480 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL4074800 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL4075722 | — | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL4083713 | — | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL4072045 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL4084164 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL4073813 | — | Ki | = | 761.0 | nM | 6.12 |
| CHEMBL4092880 | — | Ki | = | 999.0 | nM | 6.00 |
| CHEMBL4081647 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL4062461 | — | Ki | = | 1678.0 | nM | 5.78 |
| CHEMBL2018302 | TUBASTATIN A | Ki | = | 1697.0 | nM | 5.77 |
| CHEMBL3110004 | — | Ki | = | 2706.0 | nM | 5.57 |
| CHEMBL4103079 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4100615 | — | Ki | - | — | - | |
| CHEMBL4082520 | — | Ki | - | — | - | |
| CHEMBL4092802 | — | Ki | - | — | - |