Assay Detail
Binding
CHEMBL4048902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphai1 activation after 2 mins by BRET assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pEC50 | 3 | - | - |
| EC50 | 2 | 8.86 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085780 | — | — | 1 | 9.80 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.91 |
| CHEMBL3354065 | — | — | 1 | - |
| CHEMBL3354073 | — | — | 1 | - |
| CHEMBL4072818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085780 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL59 | DOPAMINE | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3354065 | — | pEC50 | - | — | - | |
| CHEMBL3354073 | — | pEC50 | - | — | - | |
| CHEMBL4072818 | — | pEC50 | - | — | - |