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Assay Detail

CHEMBL4049199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine trypsin using Boc-QAR-pNA as substrate preincubated for 1 hr followed by substrate addition measured every 30 secs for 300 secs by fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.
Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ.
J Med Chem (2018) 61 : 3674 -3684
PubMed 29605997 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.51 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4073016 1 6.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4073016 Ki = 310.0 nM 6.51