Assay Detail
Binding
CHEMBL4049253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat sEH using MNPC as substrate by fluorescence-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional epoxide hydrolase 2 (CHEMBL5669) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.08 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099452 | — | — | 1 | 8.89 |
| CHEMBL4072536 | — | — | 1 | 8.77 |
| CHEMBL4097831 | — | — | 1 | 7.85 |
| CHEMBL4083949 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099452 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4072536 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4097831 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4083949 | — | IC50 | = | 150.0 | nM | 6.82 |