Assay Detail
Binding
CHEMBL4049254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE4 (unknown origin) expressed in HEK293 cells co-expressing PM-AKAR3 assessed as increase in cAMP levels by FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.72 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097831 | — | — | 1 | 8.72 |
| CHEMBL4072536 | — | — | 1 | 8.41 |
| CHEMBL4083949 | — | — | 1 | 8.09 |
| CHEMBL4099452 | — | — | 1 | 6.89 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097831 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4072536 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4083949 | — | EC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4099452 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL63 | ROLIPRAM | EC50 | = | 340.0 | nM | 6.47 |