Assay Detail
Binding
CHEMBL4049296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BACE1 (1 to 460 residues) using CEVNLDAEFK as substrate preincubated for 10 mins followed by substrate addition measured after 6.5 hrs by TR-FRET assay
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.58 | 7.58 |
| IC50 | 1 | 9.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177913 | AZD-3839 | 1.0 | 1 | 9.22 |
| CHEMBL3989948 | LANABECESTAT | 3.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177913 | AZD-3839 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3989948 | LANABECESTAT | Ki | = | 26.0 | nM | 7.58 |