Assay Detail
ADMET
CHEMBL4049297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BACE2 (1 to 473 residues) using CEVNLDAEFK as substrate preincubated for 10 mins followed by substrate addition measured after 6.5 hrs by TR-FRET assay
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 6.43 | 6.43 |
| IC50 | 1 | 9.05 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177913 | AZD-3839 | 1.0 | 1 | 9.05 |
| CHEMBL3989948 | LANABECESTAT | 3.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177913 | AZD-3839 | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3989948 | LANABECESTAT | Ki | = | 372.0 | nM | 6.43 |