Assay Detail
Binding
CHEMBL4049313
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Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.59 | 7.18 |
| EC50 | 1 | 7.32 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.32 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.18 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 6.85 |
| CHEMBL238071 | VINDESINE | 3.0 | 1 | 6.57 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.14 |
| CHEMBL569864 | — | — | 1 | 6.01 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 5.96 |
| CHEMBL449782 | CEPHARANTHINE | 2.0 | 1 | 5.82 |
| CHEMBL2137046 | — | — | 1 | 5.71 |
| CHEMBL176045 | FANCHININ | — | 1 | 5.67 |
| CHEMBL184412 | DRONEDARONE | 4.0 | 1 | 5.66 |
| CHEMBL116590 | — | — | 1 | 5.58 |
| CHEMBL1093458 | ENDOXIFEN | 3.0 | 1 | 5.52 |
| CHEMBL399021 | — | — | 1 | 5.52 |
| CHEMBL46740 | BAZEDOXIFENE | 4.0 | 1 | 5.46 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.42 |
| CHEMBL45816 | MIBEFRADIL | 4.0 | 1 | 5.37 |
| CHEMBL609109 | THIOPROPERAZINE | 2.0 | 1 | 5.37 |
| CHEMBL4064522 | — | — | 1 | 5.21 |
| CHEMBL1946186 | DEPTROPINE | 2.0 | 1 | 5.18 |
| CHEMBL4084475 | — | — | 1 | 5.17 |
| CHEMBL471728 | — | — | 1 | 5.17 |
| CHEMBL4094679 | — | — | 1 | 5.12 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 5.12 |
| CHEMBL1213033 | APRINDINE | 2.0 | 1 | 5.11 |
| CHEMBL305660 | EBASTINE | 4.0 | 1 | 5.02 |
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 5.01 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL238071 | VINDESINE | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL569864 | — | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL2137046 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL176045 | FANCHININ | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL184412 | DRONEDARONE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL116590 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL1093458 | ENDOXIFEN | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL399021 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL46740 | BAZEDOXIFENE | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL45816 | MIBEFRADIL | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL609109 | THIOPROPERAZINE | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4064522 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL1946186 | DEPTROPINE | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL4084475 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL471728 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL4094679 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL491473 | CEDIRANIB | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL1213033 | APRINDINE | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL305660 | EBASTINE | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL346178 | OSANETANT | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL939 | GEFITINIB | IC50 | = | 9680.0 | nM | 5.01 |