Assay Detail
Binding
CHEMBL4049533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat liver cytosol HPPD using HPP as substrate assessed as reduction in O2 consumption
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Cytosol |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4-hydroxyphenylpyruvate dioxygenase (CHEMBL5863) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.62 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092919 | — | — | 1 | 7.44 |
| CHEMBL1873440 | MESOTRIONE | — | 1 | 7.43 |
| CHEMBL1337 | NITISINONE | 4.0 | 1 | 7.40 |
| CHEMBL1498742 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092919 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1873440 | MESOTRIONE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1337 | NITISINONE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1498742 | — | IC50 | = | 60000.0 | nM | 4.22 |