Assay Detail
Binding
CHEMBL4049685
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Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.14 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 6.71 |
| CHEMBL62136 | T091317 | — | 1 | 6.03 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 5.96 |
| CHEMBL456237 | LXR-623 | 1.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL62136 | T091317 | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL456237 | LXR-623 | EC50 | = | 1440.0 | nM | 5.84 |