Assay Detail
Binding
CHEMBL4049702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76V-GFP assessed as reduction in UbG76V-GFP degradation rate by fluorescence microscopic method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
26S proteasome non-ATPase regulatory subunit 14 (CHEMBL2007629) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.76 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4073553 | — | — | 1 | 6.22 |
| CHEMBL4091693 | — | — | 1 | 6.00 |
| CHEMBL4095913 | — | — | 1 | 6.00 |
| CHEMBL4070821 | — | — | 1 | 5.92 |
| CHEMBL4078891 | — | — | 1 | 5.92 |
| CHEMBL4099434 | — | — | 1 | 5.85 |
| CHEMBL4103171 | — | — | 1 | 5.58 |
| CHEMBL4093962 | — | — | 1 | 5.54 |
| CHEMBL4105598 | — | — | 1 | 5.30 |
| CHEMBL4100384 | — | — | 1 | 5.30 |
| CHEMBL4083926 | — | — | 1 | - |
| CHEMBL4062208 | — | — | 1 | - |
| CHEMBL4065318 | — | — | 1 | - |
| CHEMBL4086748 | — | — | 1 | - |
| CHEMBL4104719 | — | — | 1 | - |
| CHEMBL4080490 | — | — | 1 | - |
| CHEMBL4069023 | — | — | 1 | - |
| CHEMBL4096289 | — | — | 1 | - |
| CHEMBL4085174 | — | — | 1 | - |
| CHEMBL4103114 | — | — | 1 | - |
| CHEMBL4095417 | — | — | 1 | - |
| CHEMBL4091004 | — | — | 1 | - |
| CHEMBL4080694 | — | — | 1 | - |
| CHEMBL4059915 | — | — | 1 | - |
| CHEMBL4088568 | — | — | 1 | - |
| CHEMBL4060337 | — | — | 1 | - |
| CHEMBL4070030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4073553 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4091693 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4095913 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4070821 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4078891 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4099434 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4103171 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4093962 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4105598 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4100384 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4083926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062208 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4065318 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4086748 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL4104719 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069023 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4096289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085174 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4103114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4095417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4080694 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4059915 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4088568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4060337 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4070030 | — | IC50 | > | 100000.0 | nM | - |