Assay Detail
Functional
CHEMBL4049713
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Antiproliferative activity against human 293T cells after 72 hrs by Cell Titer-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an Inhibitor of the Proteasome Subunit Rpn11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.92 |
| CHEMBL4073553 | — | — | 1 | 5.68 |
| CHEMBL4070821 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4073553 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4070821 | — | IC50 | = | 6400.0 | nM | 5.19 |