Assay Detail
Functional
CHEMBL4050069
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Antiproliferative activity human MV4-11 cells after 72 hrs by cell titer-glo luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.21 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080362 | — | — | 1 | 6.62 |
| CHEMBL4075036 | — | — | 1 | 6.54 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.52 |
| CHEMBL4085294 | — | — | 1 | 6.30 |
| CHEMBL4101717 | — | — | 1 | 6.27 |
| CHEMBL4063679 | — | — | 1 | 6.12 |
| CHEMBL4104590 | — | — | 1 | 6.09 |
| CHEMBL4066939 | — | — | 1 | 5.95 |
| CHEMBL4060531 | — | — | 1 | 5.89 |
| CHEMBL4082425 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080362 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4075036 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4085294 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4101717 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4063679 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4104590 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4066939 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4060531 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4082425 | — | IC50 | = | 1440.0 | nM | 5.84 |