Assay Detail
Functional
CHEMBL4050079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity human SW579 cells after 72 hrs by cell titer-glo luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW579 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.93 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075036 | — | — | 1 | 6.41 |
| CHEMBL4080362 | — | — | 1 | 6.28 |
| CHEMBL4101717 | — | — | 1 | 6.15 |
| CHEMBL4104590 | — | — | 1 | 6.03 |
| CHEMBL4066939 | — | — | 1 | 5.85 |
| CHEMBL4085294 | — | — | 1 | 5.83 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.76 |
| CHEMBL4063679 | — | — | 1 | 5.72 |
| CHEMBL4082425 | — | — | 1 | 5.63 |
| CHEMBL4060531 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075036 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4080362 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4101717 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4104590 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4066939 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4085294 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4063679 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4082425 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4060531 | — | IC50 | = | 2480.0 | nM | 5.61 |