Assay Detail
Binding
CHEMBL4050188
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Inhibition of human FAK/PTK2 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.70 |
| CHEMBL4076767 | — | — | 1 | 6.05 |
| CHEMBL573339 | PI-103 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4076767 | — | IC50 | = | 891.0 | nM | 6.05 |
| CHEMBL573339 | PI-103 | IC50 | - | — | - |