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Assay Detail

CHEMBL4050279

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Binding
Inhibition of ARC-1504 binding to CK2alpha (unknown origin) (1 to 335 residues) measured after 15 mins by fluorescence anisotropic method
28
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase II subunit alpha (CHEMBL3629)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2.
Vahter J, Viht K, Uri A, Enkvist E.
Bioorg Med Chem (2017) 25 : 2277 -2284
PubMed 28274673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 28 9.27 10.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4089961 2 10.89
CHEMBL4077554 2 10.50
CHEMBL4099729 2 10.03
CHEMBL4075338 2 9.79
CHEMBL4075701 1 9.40
CHEMBL4069112 2 9.38
CHEMBL4061407 1 9.30
CHEMBL4076226 2 9.26
CHEMBL1230165 SILMITASERTIB 2.0 2 9.25
CHEMBL4077233 2 9.15
CHEMBL4091080 2 8.80
CHEMBL4072540 2 8.62
CHEMBL4070115 2 8.62
CHEMBL4067866 2 8.23
CHEMBL3696944 2 8.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4089961 Kd = 0.01288 nM 10.89
CHEMBL4089961 Kd = 0.016 nM 10.80
CHEMBL4077554 Kd = 0.03162 nM 10.50
CHEMBL4077554 Kd = 0.037 nM 10.43
CHEMBL4099729 Kd = 0.094 nM 10.03
CHEMBL4099729 Kd = 0.09333 nM 10.03
CHEMBL4075338 Kd = 0.1622 nM 9.79
CHEMBL4075338 Kd = 0.17 nM 9.77
CHEMBL4075701 Kd = 0.4 nM 9.40
CHEMBL4069112 Kd = 0.42 nM 9.38
CHEMBL4069112 Kd = 0.4169 nM 9.38
CHEMBL4061407 Kd = 0.5 nM 9.30
CHEMBL4076226 Kd = 0.55 nM 9.26
CHEMBL4076226 Kd = 0.5495 nM 9.26
CHEMBL1230165 SILMITASERTIB Kd = 0.56 nM 9.25
CHEMBL1230165 SILMITASERTIB Kd = 0.5623 nM 9.25
CHEMBL4077233 Kd = 0.71 nM 9.15
CHEMBL4077233 Kd = 0.7079 nM 9.15
CHEMBL4091080 Kd = 1.585 nM 8.80
CHEMBL4091080 Kd = 1.57 nM 8.80
CHEMBL4072540 Kd = 2.403 nM 8.62
CHEMBL4070115 Kd = 2.38 nM 8.62
CHEMBL4072540 Kd = 2.399 nM 8.62
CHEMBL4070115 Kd = 2.399 nM 8.62
CHEMBL4067866 Kd = 5.89 nM 8.23
CHEMBL4067866 Kd = 5.888 nM 8.23
CHEMBL3696944 Kd = 8.913 nM 8.05
CHEMBL3696944 Kd = 8.9 nM 8.05