Assay Detail
Binding
CHEMBL4050282
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Inhibition of CK2alpha (unknown origin) (1 to 335 residues) using 5-TAMRA-RADDSDDDDD as substrate after 30 mins by fluorescence imaging method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.54 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077554 | — | — | 1 | 8.40 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 7.70 |
| CHEMBL4067866 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077554 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4067866 | — | IC50 | = | 300.0 | nM | 6.52 |