Assay Detail
Functional
CHEMBL4050604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.49 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.29 |
| CHEMBL3186534 | RIVOCERANIB | 3.0 | 1 | 4.83 |
| CHEMBL248976 | — | — | 1 | 4.77 |
| CHEMBL248978 | — | — | 1 | 4.62 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.43 |
| CHEMBL4091675 | — | — | 1 | 4.40 |
| CHEMBL4061101 | — | — | 1 | 4.29 |
| CHEMBL4097071 | — | — | 1 | 4.26 |
| CHEMBL4093402 | — | — | 1 | 4.24 |
| CHEMBL4094326 | — | — | 1 | 4.18 |
| CHEMBL4070940 | — | — | 1 | 4.16 |
| CHEMBL4100370 | — | — | 1 | 4.14 |
| CHEMBL4077203 | — | — | 1 | 4.12 |
| CHEMBL4066132 | — | — | 1 | 4.10 |
| CHEMBL4064088 | — | — | 1 | - |
| CHEMBL4083907 | — | — | 1 | - |
| CHEMBL4062182 | — | — | 1 | - |
| CHEMBL4098031 | — | — | 1 | - |
| CHEMBL4102066 | — | — | 1 | - |
| CHEMBL4099415 | — | — | 1 | - |
| CHEMBL400102 | — | — | 1 | - |
| CHEMBL4068093 | — | — | 1 | - |
| CHEMBL4089265 | — | — | 1 | - |
| CHEMBL4089366 | — | — | 1 | - |
| CHEMBL4061215 | — | — | 1 | - |
| CHEMBL4103885 | — | — | 1 | - |
| CHEMBL4093705 | — | — | 1 | - |
| CHEMBL4074739 | — | — | 1 | - |
| CHEMBL4101424 | — | — | 1 | - |
| CHEMBL4070798 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3186534 | RIVOCERANIB | IC50 | = | 14910.0 | nM | 4.83 |
| CHEMBL248976 | — | IC50 | = | 16970.0 | nM | 4.77 |
| CHEMBL248978 | — | IC50 | = | 24240.0 | nM | 4.62 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL4091675 | — | IC50 | = | 39520.0 | nM | 4.40 |
| CHEMBL4061101 | — | IC50 | = | 51360.0 | nM | 4.29 |
| CHEMBL4097071 | — | IC50 | = | 55420.0 | nM | 4.26 |
| CHEMBL4093402 | — | IC50 | = | 57660.0 | nM | 4.24 |
| CHEMBL4094326 | — | IC50 | = | 66120.0 | nM | 4.18 |
| CHEMBL4070940 | — | IC50 | = | 69970.0 | nM | 4.16 |
| CHEMBL4100370 | — | IC50 | = | 72550.0 | nM | 4.14 |
| CHEMBL4077203 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL4066132 | — | IC50 | = | 78920.0 | nM | 4.10 |
| CHEMBL4077805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085660 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4066822 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4085007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4104472 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073532 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4064088 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4083907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4062182 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4098031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4102066 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4099415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL400102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068093 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089265 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089366 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061215 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4103885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4074739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101424 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4070798 | — | IC50 | > | 100000.0 | nM | - |