Assay Detail
Functional
CHEMBL4050865
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Antiproliferative activity against human A549 cells assessed as reduction in viability after 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.49 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356793 | — | — | 1 | 9.15 |
| CHEMBL4062427 | — | — | 1 | 9.10 |
| CHEMBL4071263 | — | — | 1 | 9.00 |
| CHEMBL4078516 | — | — | 1 | 8.92 |
| CHEMBL4077511 | — | — | 1 | 7.92 |
| CHEMBL4087766 | — | — | 1 | 7.89 |
| CHEMBL4062615 | — | — | 1 | 7.80 |
| CHEMBL4095887 | — | — | 1 | 7.66 |
| CHEMBL4073984 | — | — | 1 | 7.54 |
| CHEMBL4084311 | — | — | 1 | 7.52 |
| CHEMBL4103647 | — | — | 1 | 7.52 |
| CHEMBL4081801 | — | — | 1 | 7.31 |
| CHEMBL4069999 | — | — | 1 | 7.28 |
| CHEMBL4061605 | — | — | 1 | 6.99 |
| CHEMBL4088483 | — | — | 1 | 6.94 |
| CHEMBL4099812 | — | — | 1 | 6.74 |
| CHEMBL4085716 | — | — | 1 | 6.72 |
| CHEMBL4100757 | — | — | 1 | 6.56 |
| CHEMBL399454 | — | — | 1 | 6.55 |
| CHEMBL4092065 | — | — | 1 | 6.34 |
| CHEMBL4093462 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356793 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4062427 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4071263 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4078516 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4077511 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4087766 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4062615 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4095887 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4073984 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4084311 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4103647 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4081801 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4069999 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4061605 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4088483 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4099812 | — | IC50 | = | 181.9 | nM | 6.74 |
| CHEMBL4085716 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4100757 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL399454 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL4092065 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL4093462 | — | IC50 | = | 1534.0 | nM | 5.81 |