Assay Detail
Functional
CHEMBL4052004
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Antiviral activity against Influenza A virus A//HK/7/87 (H3N2) expressing wild-type M2 proton channel infected in MDCK cells assessed as reduction in plaque formation preincubated with virus for 1 hr followed by addition to cells measured after 72 hrs by crystal violet staining based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Hong Kong/7/1987(H3N2)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.50 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.80 |
| CHEMBL4104405 | — | — | 1 | 6.85 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.85 |
| CHEMBL294443 | — | — | 1 | 6.00 |
| CHEMBL4092431 | — | — | 1 | 5.00 |
| CHEMBL4094873 | — | — | 1 | - |
| CHEMBL4074389 | — | — | 1 | - |
| CHEMBL4059787 | — | — | 1 | - |
| CHEMBL4064734 | — | — | 1 | - |
| CHEMBL4073320 | — | — | 1 | - |
| CHEMBL4100170 | — | — | 1 | - |
| CHEMBL4070224 | — | — | 1 | - |
| CHEMBL4061974 | — | — | 1 | - |
| CHEMBL4096027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4104405 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL660 | AMANTADINE | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL294443 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4092431 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4094873 | — | EC50 | - | — | - | |
| CHEMBL4074389 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4059787 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4064734 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4073320 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4100170 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4070224 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4061974 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4096027 | — | EC50 | > | 10000.0 | nM | - |