Assay Detail
Functional
CHEMBL4052178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 10.60 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086979 | — | — | 1 | 10.60 |
| CHEMBL5314341 | GLUCAGON | 4.0 | 1 | - |
| CHEMBL414357 | EXENATIDE | 4.0 | 1 | - |
| CHEMBL410972 | — | — | 1 | - |
| CHEMBL4524066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086979 | — | EC50 | = | 0.025 | nM | 10.60 |
| CHEMBL5314341 | GLUCAGON | EC50 | = | 0.0013 | nM | - |
| CHEMBL414357 | EXENATIDE | EC50 | > | 10000.0 | nM | - |
| CHEMBL410972 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4524066 | — | EC50 | > | 10000.0 | nM | - |