Assay Detail
Functional
CHEMBL4052191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as inhibition of NDP-MSH induced-cAMP accumulation after 2 hrs by alpha screen assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.57 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068643 | — | — | 1 | 5.80 |
| CHEMBL4089759 | — | — | 1 | 5.70 |
| CHEMBL4084136 | — | — | 1 | 5.60 |
| CHEMBL4080138 | — | — | 1 | 5.60 |
| CHEMBL4068777 | — | — | 1 | 5.60 |
| CHEMBL4099096 | — | — | 1 | 5.40 |
| CHEMBL4105142 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068643 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL4089759 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL4084136 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL4080138 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL4068777 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL4099096 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL4105142 | — | Kd | = | 5011.87 | nM | 5.30 |