Assay Detail
Binding
CHEMBL4052391
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Inhibition of HIV1 3B reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus induced cytotoxicity after 5 days by MTT assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 7.20 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3929927 | — | — | 1 | 8.54 |
| CHEMBL4094163 | — | — | 1 | 8.32 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.29 |
| CHEMBL4066621 | — | — | 1 | 8.25 |
| CHEMBL4075243 | — | — | 1 | 8.19 |
| CHEMBL4059713 | — | — | 1 | 8.18 |
| CHEMBL4090492 | — | — | 1 | 8.14 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.14 |
| CHEMBL4080133 | — | — | 1 | 8.13 |
| CHEMBL4062507 | — | — | 1 | 8.12 |
| CHEMBL4088003 | — | — | 1 | 8.07 |
| CHEMBL4101895 | — | — | 1 | 8.07 |
| CHEMBL4085465 | — | — | 1 | 8.06 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.84 |
| CHEMBL4084357 | — | — | 1 | 7.76 |
| CHEMBL4104988 | — | — | 1 | 7.64 |
| CHEMBL4060732 | — | — | 1 | 7.55 |
| CHEMBL4090441 | — | — | 1 | 7.53 |
| CHEMBL4101836 | — | — | 1 | 7.50 |
| CHEMBL4069411 | — | — | 1 | 7.49 |
| CHEMBL4083835 | — | — | 1 | 7.47 |
| CHEMBL4096564 | — | — | 1 | 7.46 |
| CHEMBL4093229 | — | — | 1 | 7.45 |
| CHEMBL4078540 | — | — | 1 | 7.43 |
| CHEMBL4067573 | — | — | 1 | 7.39 |
| CHEMBL4082607 | — | — | 1 | 7.37 |
| CHEMBL4094991 | — | — | 1 | 6.89 |
| CHEMBL4077355 | — | — | 1 | 6.89 |
| CHEMBL4078474 | — | — | 1 | 6.88 |
| CHEMBL4103275 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3929927 | — | EC50 | = | 2.91 | nM | 8.54 |
| CHEMBL4094163 | — | EC50 | = | 4.74 | nM | 8.32 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.19 | nM | 8.29 |
| CHEMBL4066621 | — | EC50 | = | 5.62 | nM | 8.25 |
| CHEMBL4075243 | — | EC50 | = | 6.41 | nM | 8.19 |
| CHEMBL4059713 | — | EC50 | = | 6.59 | nM | 8.18 |
| CHEMBL4090492 | — | EC50 | = | 7.26 | nM | 8.14 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4080133 | — | EC50 | = | 7.46 | nM | 8.13 |
| CHEMBL4062507 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4088003 | — | EC50 | = | 8.53 | nM | 8.07 |
| CHEMBL4101895 | — | EC50 | = | 8.48 | nM | 8.07 |
| CHEMBL4085465 | — | EC50 | = | 8.69 | nM | 8.06 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4084357 | — | EC50 | = | 17.4 | nM | 7.76 |
| CHEMBL4104988 | — | EC50 | = | 23.1 | nM | 7.64 |
| CHEMBL4060732 | — | EC50 | = | 27.9 | nM | 7.55 |
| CHEMBL4090441 | — | EC50 | = | 29.6 | nM | 7.53 |
| CHEMBL4101836 | — | EC50 | = | 31.6 | nM | 7.50 |
| CHEMBL4069411 | — | EC50 | = | 32.3 | nM | 7.49 |
| CHEMBL4083835 | — | EC50 | = | 33.5 | nM | 7.47 |
| CHEMBL4096564 | — | EC50 | = | 34.9 | nM | 7.46 |
| CHEMBL4093229 | — | EC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4078540 | — | EC50 | = | 37.4 | nM | 7.43 |
| CHEMBL4067573 | — | EC50 | = | 40.8 | nM | 7.39 |
| CHEMBL4082607 | — | EC50 | = | 43.2 | nM | 7.37 |
| CHEMBL4077355 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4094991 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4078474 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4103275 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4086331 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4076005 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4094095 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4102745 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4085345 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4074049 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 271.0 | nM | 6.57 |
| CHEMBL4072495 | — | EC50 | = | 498.0 | nM | 6.30 |
| CHEMBL4062672 | — | EC50 | = | 607.0 | nM | 6.22 |
| CHEMBL4063892 | — | EC50 | = | 805.0 | nM | 6.09 |
| CHEMBL4093101 | — | EC50 | = | 857.0 | nM | 6.07 |
| CHEMBL4075094 | — | EC50 | = | 891.0 | nM | 6.05 |
| CHEMBL4065430 | — | EC50 | = | 935.0 | nM | 6.03 |
| CHEMBL4095529 | — | EC50 | = | 946.0 | nM | 6.02 |
| CHEMBL4061597 | — | EC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4061608 | — | EC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4100811 | — | EC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL4089725 | — | EC50 | >= | 1310.0 | nM | - |
| CHEMBL4079259 | — | EC50 | > | 5150.0 | nM | - |
| CHEMBL4097283 | — | EC50 | > | 707.0 | nM | - |