Assay Detail
Functional
CHEMBL4052453
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Cytotoxicity against wild type p53 expressing human U2OS cells assessed as cell growth inhibition after 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.19 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152332 | — | — | 1 | 5.58 |
| CHEMBL4081423 | — | — | 1 | 5.43 |
| CHEMBL4085272 | — | — | 1 | 5.24 |
| CHEMBL4077617 | — | — | 1 | 5.14 |
| CHEMBL4093959 | — | — | 1 | 4.96 |
| CHEMBL4078749 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152332 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4081423 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4085272 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4077617 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL4093959 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL4078749 | — | IC50 | = | 17420.0 | nM | 4.76 |