Assay Detail
Binding
CHEMBL4052528
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Inhibition of recombinant full length HIV1 reverse transcriptase RNase H domain using RNA/DNA duplex substrate HTS1 assessed as reduction in internal cleavage of RNA strand by fluoresence assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.20 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085120 | — | — | 1 | 8.40 |
| CHEMBL4097509 | — | — | 1 | 7.80 |
| CHEMBL4074881 | — | — | 1 | 7.75 |
| CHEMBL4087618 | — | — | 1 | 7.72 |
| CHEMBL4063811 | — | — | 1 | 7.72 |
| CHEMBL4068663 | — | — | 1 | 7.57 |
| CHEMBL4103071 | — | — | 1 | 7.52 |
| CHEMBL4089779 | — | — | 1 | 7.50 |
| CHEMBL4095319 | — | — | 1 | 7.42 |
| CHEMBL4081916 | — | — | 1 | 7.42 |
| CHEMBL4086006 | — | — | 1 | 7.40 |
| CHEMBL4079744 | — | — | 1 | 7.39 |
| CHEMBL4075721 | — | — | 1 | 7.33 |
| CHEMBL4098419 | — | — | 1 | 7.33 |
| CHEMBL4088773 | — | — | 1 | 7.31 |
| CHEMBL4073058 | — | — | 1 | 7.30 |
| CHEMBL4085394 | — | — | 1 | 7.27 |
| CHEMBL4071378 | — | — | 1 | 7.27 |
| CHEMBL4079475 | — | — | 1 | 7.25 |
| CHEMBL4104008 | — | — | 1 | 7.24 |
| CHEMBL4064482 | — | — | 1 | 7.23 |
| CHEMBL4093761 | — | — | 1 | 7.11 |
| CHEMBL4066264 | — | — | 1 | 7.10 |
| CHEMBL4083483 | — | — | 1 | 6.96 |
| CHEMBL4076618 | — | — | 1 | 6.96 |
| CHEMBL4060013 | — | — | 1 | 6.92 |
| CHEMBL4078736 | — | — | 1 | 6.85 |
| CHEMBL4071684 | — | — | 1 | 6.70 |
| CHEMBL4061749 | — | — | 1 | 6.60 |
| CHEMBL4088905 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085120 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4097509 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4074881 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4087618 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4063811 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4068663 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4103071 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4089779 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4095319 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4081916 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4086006 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4079744 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4075721 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4098419 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4088773 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4073058 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4071378 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4085394 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4079475 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4104008 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4064482 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4093761 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4066264 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4083483 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4076618 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4060013 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4078736 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4071684 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4061749 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4088905 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4067680 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4101479 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | > | 10000.0 | nM | - |
| CHEMBL1229211 | DOLUTEGRAVIR | IC50 | > | 10000.0 | nM | - |