Assay Detail
Binding
CHEMBL4052530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV integrase strand transfer activity expressed in Escherichia coli BL21 (DE3) using 5' biotin ATGTGGAAAATCTCTAGCA primer annealed with ACTGCTAGAGATTTTCCACAT 3' Cy5 template preincubated for 10 mins followed by primer/template addition measured after 30 mins by fluorescence assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.50 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229211 | DOLUTEGRAVIR | 4.0 | 1 | 7.17 |
| CHEMBL4089779 | — | — | 1 | 6.85 |
| CHEMBL4079475 | — | — | 1 | 6.64 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 6.19 |
| CHEMBL4097509 | — | — | 1 | 5.82 |
| CHEMBL4071378 | — | — | 1 | 5.80 |
| CHEMBL4103071 | — | — | 1 | 5.58 |
| CHEMBL4085120 | — | — | 1 | 5.51 |
| CHEMBL4074881 | — | — | 1 | 5.50 |
| CHEMBL4095319 | — | — | 1 | 5.02 |
| CHEMBL4104008 | — | — | 1 | 4.68 |
| CHEMBL4083483 | — | — | 1 | 4.64 |
| CHEMBL4066264 | — | — | 1 | 4.54 |
| CHEMBL4063811 | — | — | 1 | 4.47 |
| CHEMBL4087618 | — | — | 1 | 4.15 |
| CHEMBL4088773 | — | — | 1 | - |
| CHEMBL4086006 | — | — | 1 | - |
| CHEMBL4064482 | — | — | 1 | - |
| CHEMBL4093761 | — | — | 1 | - |
| CHEMBL4073058 | — | — | 1 | - |
| CHEMBL4078736 | — | — | 1 | - |
| CHEMBL4076618 | — | — | 1 | - |
| CHEMBL4098419 | — | — | 1 | - |
| CHEMBL4060013 | — | — | 1 | - |
| CHEMBL4081916 | — | — | 1 | - |
| CHEMBL4061749 | — | — | 1 | - |
| CHEMBL4071684 | — | — | 1 | - |
| CHEMBL4085394 | — | — | 1 | - |
| CHEMBL4068663 | — | — | 1 | - |
| CHEMBL4079744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229211 | DOLUTEGRAVIR | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4089779 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4079475 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4097509 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4071378 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4103071 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4085120 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4074881 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4095319 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4104008 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4083483 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4066264 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4063811 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4087618 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4067680 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4088905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101479 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4075721 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4088773 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4086006 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4064482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4073058 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4078736 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4098419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4060013 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4081916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4061749 | — | IC50 | - | — | - | |
| CHEMBL4071684 | — | IC50 | - | — | - | |
| CHEMBL4085394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068663 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4079744 | — | IC50 | > | 100000.0 | nM | - |