Assay Detail
Binding
CHEMBL4052936
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Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by MicroBeta microplate counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.78 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165677 | — | — | 1 | 8.47 |
| CHEMBL4093656 | — | — | 1 | 8.00 |
| CHEMBL4092928 | — | — | 1 | 7.03 |
| CHEMBL346692 | — | — | 1 | 6.99 |
| CHEMBL4081424 | — | — | 1 | 6.70 |
| CHEMBL3589651 | — | — | 1 | 6.57 |
| CHEMBL4105681 | — | — | 1 | 6.50 |
| CHEMBL4085184 | — | — | 1 | 6.50 |
| CHEMBL1627306 | — | — | 1 | 6.36 |
| CHEMBL4072171 | — | — | 1 | 6.23 |
| CHEMBL1627307 | — | — | 1 | 6.15 |
| CHEMBL4063564 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165677 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4093656 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4092928 | — | Ki | = | 93.1 | nM | 7.03 |
| CHEMBL346692 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL4081424 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL3589651 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL4105681 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL4085184 | — | Ki | = | 317.0 | nM | 6.50 |
| CHEMBL1627306 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL4072171 | — | Ki | = | 588.0 | nM | 6.23 |
| CHEMBL1627307 | — | Ki | = | 715.0 | nM | 6.15 |
| CHEMBL4063564 | — | Ki | = | 1400.0 | nM | 5.85 |