Assay Detail
Binding
CHEMBL4052937
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Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by MicroBeta microplate counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.03 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093656 | — | — | 1 | 9.76 |
| CHEMBL1627306 | — | — | 1 | 8.95 |
| CHEMBL346692 | — | — | 1 | 8.85 |
| CHEMBL2165677 | — | — | 1 | 8.72 |
| CHEMBL4081424 | — | — | 1 | 8.38 |
| CHEMBL3589651 | — | — | 1 | 8.37 |
| CHEMBL1627307 | — | — | 1 | 7.78 |
| CHEMBL4105681 | — | — | 1 | 7.63 |
| CHEMBL4092928 | — | — | 1 | 7.46 |
| CHEMBL4085184 | — | — | 1 | 7.12 |
| CHEMBL4072171 | — | — | 1 | 6.92 |
| CHEMBL4063564 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093656 | — | Ki | = | 0.172 | nM | 9.76 |
| CHEMBL1627306 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL346692 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2165677 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4081424 | — | Ki | = | 4.12 | nM | 8.38 |
| CHEMBL3589651 | — | Ki | = | 4.26 | nM | 8.37 |
| CHEMBL1627307 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL4105681 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL4092928 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL4085184 | — | Ki | = | 75.2 | nM | 7.12 |
| CHEMBL4072171 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL4063564 | — | Ki | = | 373.0 | nM | 6.43 |