Assay Detail
Binding
CHEMBL4053085
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Inhibition of ATP synthase in Mycobacterium smegmatis inverted membrane vesicles using NADH as substrate incubated for 60 mins by luciferin-luciferase reaction based bioluminescence assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.45 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071306 | — | — | 1 | 8.30 |
| CHEMBL4069282 | — | — | 1 | 7.70 |
| CHEMBL4098974 | — | — | 1 | 7.52 |
| CHEMBL4101131 | — | — | 1 | 7.52 |
| CHEMBL4060601 | — | — | 1 | 7.40 |
| CHEMBL4096519 | — | — | 1 | 7.30 |
| CHEMBL4086215 | — | — | 1 | 7.30 |
| CHEMBL4072726 | — | — | 1 | 7.22 |
| CHEMBL4089090 | — | — | 1 | 7.22 |
| CHEMBL4060124 | — | — | 1 | 7.16 |
| CHEMBL4104123 | — | — | 1 | 7.10 |
| CHEMBL4088823 | — | — | 1 | 7.10 |
| CHEMBL4096794 | — | — | 1 | 7.05 |
| CHEMBL4070305 | — | — | 1 | 6.89 |
| CHEMBL4094369 | — | — | 1 | 6.80 |
| CHEMBL4078337 | — | — | 1 | 6.68 |
| CHEMBL4080795 | — | — | 1 | 6.52 |
| CHEMBL4088671 | — | — | 1 | 6.40 |
| CHEMBL4096383 | — | — | 1 | 6.16 |
| CHEMBL4070947 | — | — | 1 | 6.11 |
| CHEMBL4066870 | — | — | 1 | 5.25 |
| CHEMBL4078770 | — | — | 1 | 5.19 |
| CHEMBL4105022 | — | — | 1 | 5.14 |
| CHEMBL4072269 | — | — | 1 | 5.08 |
| CHEMBL4078294 | — | — | 1 | 5.02 |
| CHEMBL4086623 | — | — | 1 | 4.72 |
| CHEMBL4104517 | — | — | 1 | 4.44 |
| CHEMBL4093027 | — | — | 1 | 4.18 |
| CHEMBL4067879 | — | — | 1 | - |
| CHEMBL4069064 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071306 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4069282 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4098974 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4101131 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4060601 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4096519 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4086215 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4072726 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4089090 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4060124 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4104123 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4088823 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4096794 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4070305 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4094369 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4078337 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4080795 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4088671 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4096383 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4070947 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4066870 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4078770 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4105022 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4072269 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4078294 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4086623 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4104517 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL4093027 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL4067879 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL4069064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4097303 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4080941 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091232 | — | IC50 | < | 20.0 | nM | - |