Assay Detail
Binding
CHEMBL4053402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1 to 42) aggregation in Escherichia coli competent cells BL21 (DE3) after overnight incubation by Thioflavin-S steady-state fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli BL21(DE3) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.52 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.82 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.82 |
| CHEMBL3348861 | AMPELOPSIN | 2.0 | 1 | 4.60 |
| CHEMBL28626 | MORIN | — | 1 | 4.52 |
| CHEMBL503168 | DATISCETIN | — | 1 | 4.26 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.12 |
| CHEMBL309490 | GALANGIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL164 | MYRICETIN | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3348861 | AMPELOPSIN | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL28626 | MORIN | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL503168 | DATISCETIN | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL309490 | GALANGIN | IC50 | > | 500000.0 | nM | - |