Assay Detail
Binding
CHEMBL4053620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins in presence of Ca2+ ionophore A23187 by RP-HPLC analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.40 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242095 | — | — | 1 | 5.85 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.77 |
| CHEMBL488313 | — | — | 1 | 5.64 |
| CHEMBL1984096 | — | — | 1 | 5.35 |
| CHEMBL4096534 | — | — | 1 | 5.30 |
| CHEMBL4077368 | — | — | 1 | 5.30 |
| CHEMBL4078358 | — | — | 1 | 5.28 |
| CHEMBL4087914 | — | — | 1 | 5.20 |
| CHEMBL4075212 | — | — | 1 | 5.20 |
| CHEMBL1992376 | ACROFOLIONE A | — | 1 | 5.14 |
| CHEMBL29097 | — | — | 1 | - |
| CHEMBL4069303 | — | — | 1 | - |
| CHEMBL4080027 | — | — | 1 | - |
| CHEMBL4104264 | — | — | 1 | - |
| CHEMBL1241050 | — | — | 1 | - |
| CHEMBL4101532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242095 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL488313 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1984096 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4096534 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4077368 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4078358 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4087914 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4075212 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1992376 | ACROFOLIONE A | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL29097 | — | IC50 | - | — | - | |
| CHEMBL4069303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4080027 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4104264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1241050 | — | IC50 | - | — | - | |
| CHEMBL4101532 | — | IC50 | > | 10000.0 | nM | - |