Assay Detail
ADMET
CHEMBL4053660
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Antiproliferative activity against human PWR-1E cells after 3 days by WST-1 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PWR-1E |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.21 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065705 | — | — | 1 | 7.42 |
| CHEMBL4090481 | — | — | 1 | 7.32 |
| CHEMBL4098134 | — | — | 1 | 6.71 |
| CHEMBL3763425 | — | — | 1 | 6.64 |
| CHEMBL3763602 | — | — | 1 | 6.62 |
| CHEMBL4076566 | — | — | 1 | 6.51 |
| CHEMBL4086611 | — | — | 1 | 6.50 |
| CHEMBL3765782 | — | — | 1 | 6.48 |
| CHEMBL4104530 | — | — | 1 | 6.41 |
| CHEMBL4074414 | — | — | 1 | 6.40 |
| CHEMBL4098154 | — | — | 1 | 6.39 |
| CHEMBL4094378 | — | — | 1 | 6.36 |
| CHEMBL4066242 | — | — | 1 | 6.31 |
| CHEMBL4065086 | — | — | 1 | 6.30 |
| CHEMBL4072615 | — | — | 1 | 6.27 |
| CHEMBL4104463 | — | — | 1 | 6.24 |
| CHEMBL4102117 | — | — | 1 | 6.21 |
| CHEMBL3764186 | — | — | 1 | 6.10 |
| CHEMBL4079389 | — | — | 1 | 5.87 |
| CHEMBL3764375 | — | — | 1 | 5.84 |
| CHEMBL3764225 | — | — | 1 | 5.57 |
| CHEMBL3765359 | — | — | 1 | 5.31 |
| CHEMBL3764322 | — | — | 1 | 5.30 |
| CHEMBL3765753 | — | — | 1 | 5.19 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.09 |
| CHEMBL3763797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065705 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4090481 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4098134 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL3763425 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3763602 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4076566 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4086611 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3765782 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4104530 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4074414 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4098154 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4094378 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4066242 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4065086 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4072615 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4104463 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4102117 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3764186 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4079389 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3764375 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL3764225 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL3765359 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL3764322 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL3765753 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL140 | CURCUMIN | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL3763797 | — | IC50 | < | 1000.0 | nM | - |